Articles from Evecxia Therapeutics, Inc.

Evecxia Therapeutics, Inc.—a clinical-stage neuroscience company developing a novel class of Serotonin Synthesis Amplification therapies—today announced the publication of the peer-reviewed article titled “Serotonin Synthesis Amplification to Augment the Therapeutic Efficacy of Serotonin Reuptake Inhibitor Antidepressants - Five Decades of Clinical Evidence” in the Journal of Clinical Psychopharmacology. The review article was co-authored with Dr. Stefania Chaikali, MD, MS, of the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, and is freely available via open access (LINK).

Evecxia Therapeutics, Inc.—a clinical-stage neuroscience company developing a novel class of Serotonin Synthesis Amplification therapies—today announced that the first patient has been dosed in a Phase 1b randomized, placebo-controlled target-engagement study in patients with depression and treated with serotonin reuptake inhibitor antidepressants.

Evecxia Therapeutics, Inc., a biopharmaceutical company focused on the development of therapeutics for central nervous system (CNS) disorders, today announced it has completed a new financing round, with gross proceeds of approximately $5.0 million. This financing will fund clinical, non-clinical and CMC activities in anticipation of our plans to initiate an adequate, placebo-controlled Phase 2 clinical study evaluating EVX-101, as adjunctive therapy, in patients with obsessive-compulsive disorder (OCD) with inadequate response to first-line selective serotonin-reuptake inhibitors (SSRIs). Collage Venture Partners acted as the sole book-running manager for the offering with existing investors.

Evecxia Therapeutics, Inc., the leader in serotonin synthesis amplification to treat neuropsychiatric disorders, today announced the appointments of Allan L. Shaw and Elliot Ehrich, MD to its Board of Directors, bringing with them decades of leadership experience in the biopharmaceutical industry.

Evecxia Therapeutics, Inc., the leader in serotonin synthesis amplification to treat brain disorders, today announced the absence of toxicity findings associated with the co-administration of EVX-101 in conjunction with the first-line antidepressant fluoxetine in nonclinical GLP toxicology studies. These favorable results support the safety profile of the lead drug candidate, EVX‑101, in a planned Phase 2 clinical trial in patients with major depressive disorder inadequately responding to first‑line antidepressant therapy.

Evecxia Therapeutics, Inc., the leader in serotonin synthesis amplification to treat brain disorders, today announced that Dr. Jacob Jacobsen has been appointed President and CEO. Dr. Jacobsen succeeds Joseph Patti, Ph.D., who has stepped down from his role as President and CEO of Evecxia to pursue other interests.

Evecxia Therapeutics, Inc., the leader in serotonin synthesis amplification to treat brain disorders, today announced that an oral presentation, “The Therapeutic Potential of EVX-101 to Amplify Serotonin Synthesis for the Adjunctive Treatment of MDD and Other Mental Illness: Emerging Profile and Post-Phase 1 Update”, will be presented during the Pharmaceutical Pipeline Session on May 30th by Dr. Jacobson, Chief Scientific Officer, at the 2023 ASCP Meeting in Miami Beach, FL.

Evecxia Therapeutics, Inc., the leader in serotonin synthesis amplification to treat brain disorders, today announced that the U.S. Patent and Trademark Office has allowed U.S. patent application 17/877,699.

Evecxia Therapeutics, Inc. today announced favorable safety, tolerability, pharmacokinetic, and pharmacodynamic data from a double-blind, placebo-controlled Phase 1, a two-part single ascending dose (SAD) and multiple ascending dose (MAD) trial of EVX-101 in healthy volunteers treated with escitalopram. The Company further announced the planned design of a Phase 2 adjunctive EVX-101 trial in patients with major depressive disorder (MDD) responding inadequately to a first-line antidepressant (selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI)).

Evecxia Therapeutics, Inc. announced favorable safety, tolerability, pharmacokinetics, and pharmacodynamics data from a double-blind, placebo-controlled Phase 1 single ascending dose study of EVX-301 in healthy volunteers pre-treated with escitalopram for three weeks. The Company also announced the planned design of a Phase 2a study to treat ongoing suicidal ideation in patients with Major Depressive Disorder responding inadequately to a first-line antidepressant (selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI).

Evecxia Therapeutics, a clinical stage biopharmaceutical company dedicated to realizing the therapeutic potential of serotonin synthesis amplification for the treatment of brain disorders, today announced that Joseph M. Patti, Ph.D., has been appointed President and Chief Executive Officer and a member of Evecxia’s board of directors. Dr. Patti brings extensive drug development and executive leadership expertise, including serving in multiple CEO roles, and as co-founder, Chief Scientific Officer and Senior Vice President of Research & Development of Inhibitex, Inc. until its $2.5 billion acquisition by Bristol Myers Squibb. Dr. Patti succeeds John J. Kaiser, who has retired but will continue to serve as a member of Evecxia’s board of directors.

Evecxia Therapeutics today announced the issuance by the United States Patent and Trademark Office (USPTO) of an additional patent covering EVX-101.